rs11640534 - FBXL19
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis - Unknown journal (n.d.) · Unknown authors · PubMed 39885523
ABSTRACT: Background Psoriasis is a common chronic, recurrent, immune-mediated disease involved in the skin or joints or both. However, deeper insight into the genetic susceptibility of psoriasis is still unclear. Methods Here we performed the largest multi-ancestry meta-analysis of genome-wide association study including 28,869 psoriasis cases and 443,950 healthy controls. Results We identified 74 genome-wide significant loci for psoriasis. Of 74 loci, 32 were novel psoriasis risk loci. Across 74 loci, 801 likely causal genes are indicated and 164 causal genes are prioritized. SNP-based heritability analyses demonstrated that common variants explain 15% of genetic risk for psoriasis. Gene-set analyses and the genetic correlation revealed that psoriasis-related genes have the positive corr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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ITGAX-targeted strategies for psoriasis Moderate
ITGAX is identified as a druggable, causal gene for psoriasis with available therapeutic targets.
Discuss preventive approaches and ITGAX-targeting drug options with dermatologist.
Screening
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Baseline dermatology evaluation for psoriasis Moderate
Genetic variation in ITGAX significantly increases psoriasis susceptibility (p=1.31e-14).
Consider baseline skin evaluation; monitor for development of plaques, scaling, or erythema.