rs116386365 - IL17A - IL17F

Magnitude 4.5 · 1 study on file

Reported associations

• Association with HLA-DRβ1 position 37 distinguishes juvenile dermatomyositis from adult-onset myositis - Unknown journal (n.d.) · Unknown authors · PubMed 35094092

  ABSTRACT: Abstract Juvenile dermatomyositis (JDM) is a rare, severe autoimmune disease and the most common idiopathic inflammatory myopathy of children. JDM and adult-onset dermatomyositis (DM) have similar clinical, biological and serological features, although these features differ in prevalence between childhood-onset and adult-onset disease, suggesting that age of disease onset may influence pathogenesis. Therefore, a JDM-focused genetic analysis was performed using the largest collection of JDM samples to date. Caucasian JDM samples (n = 952) obtained via international collaboration were genotyped using the Illumina HumanCoreExome chip. Additional non-assayed human leukocyte antigen (HLA) loci and genome-wide single-nucleotide polymorphisms (SNPs) were imputed. HLA-DRB1*03:01 was

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