rs11638064 - SMAD3
Magnitude 2.2 · 2 studies on file
Reported associations
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Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation - Unknown journal (n.d.) · Unknown authors · PubMed 27841878
ABSTRACT: Longitudinal electronic health records on 99,785 Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort individuals provided 1,342,814 systolic and diastolic blood pressure measurements for a genome-wide association study on long-term average systolic, diastolic, and pulse pressure. We identified 39 novel among 75 significant loci (P≤5×10−8), most replicating in the combined International Consortium for Blood Pressure (ICBP, n=69,396) and UK Biobank (UKB, n=152,081) studies. Combining GERA with ICBP yielded 36 additional novel loci, most replicating in UKB. Combining all three studies (n=321,262) yielded 241 additional genome-wide significant loci, although for these no replication sample was available. All associated loci explained 2.9%/2.5%/3.1% of systolic/
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Glucose hypometabolism in the Auditory Pathway in Age Related Hearing Loss in the ADNI cohort - Unknown journal (n.d.) · Unknown authors · PubMed 34624637
ABSTRACT: Highlights The voxel-wise comparison between older adults with hearing loss and without hearing loss revealed FDG hypometabolism in bilateral Heschl's gyrus. Additional FDG hypometabolism in the inferior colliculus and cochlear nucleus was localized after age-adjustment. Decline in FDG metabolism in the cochlear nucleus was accelerated in people with hearing loss. Various genetic loci demonstrated suggestive associations with glucose metabolism in hearing loss-associated brain regions. Purpose Hearing loss (HL) is one of the most common age-related diseases. Here, we investigate the central auditory correlates of HL in people with normal cognition and mild cognitive impairment (MCI) and test their association with genetic markers with the aim of revealing pathogenic mechanisms.
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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hearing function for age-related hearing loss Low
genetic variant associated with reduced glucose metabolism in cochlear nucleus, linked to age-related hearing loss and dementia risk
annual audiometric testing starting at age 40-50
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blood pressure and pulse pressure Moderate
genetic variant genome-wide significantly associated with elevated pulse pressure, a cardiovascular risk marker
regular blood pressure monitoring; consider 24-hour ambulatory BP monitoring if elevated