rs11637783 - MORF4L1
Magnitude 2.2 · 1 study on file
Reported associations
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Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease - Unknown journal (n.d.) · Unknown authors · PubMed 29212778
ABSTRACT: Supplemental Digital Content is available in the text. Rationale: Coronary artery disease (CAD) is a complex phenotype driven by genetic and environmental factors. Ninety-seven genetic risk loci have been identified to date, but the identification of additional susceptibility loci might be important to enhance our understanding of the genetic architecture of CAD. Objective: To expand the number of genome-wide significant loci, catalog functional insights, and enhance our understanding of the genetic architecture of CAD. Methods and Results: We performed a genome-wide association study in 34 541 CAD cases and 261 984 controls of UK Biobank resource followed by replication in 88 192 cases and 162 544 controls from CARDIoGRAMplusC4D. We identified 75 loci that replicated and
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Lipid panel and blood pressure monitoring Moderate
CAD-associated variants increase cardiovascular event risk; lipid and BP control are modifiable risk factors.
Check lipid panel and blood pressure annually, or more frequently per cardiologist discretion.
Diet
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Mediterranean-style diet Moderate
Reduction in LDL oxidation and inflammation, evidenced to reduce CAD events in at-risk populations.
Emphasize olive oil, fish, vegetables, legumes; limit red meat and refined carbohydrates.
Discuss with your doctor
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Preventive cardiology consultation for risk stratification Moderate
GWAS-identified genetic risk warrants specialist assessment for personalized prevention strategies.
Request cardiology evaluation to discuss family history, additional risk factors, and need for pharmacological prevention.
Exercise
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Aerobic exercise for cardiovascular protection Moderate
Regular aerobic activity reduces CAD risk through improved endothelial function and lipid profiles in genetically predisposed individuals.
150 minutes moderate-intensity aerobic exercise per week, spread over at least 3 days.
Screening
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Cardiovascular risk assessment starting at age 35 Moderate
GWAS-identified risk allele for coronary artery disease in MORF4L1 locus increases baseline CAD susceptibility.
Baseline lipid panel, blood pressure, and ECG; repeat annually or per cardiologist guidance.