rs11637027 - MAP2K5
Magnitude 2.2 · 2 studies on file
Reported associations
-
A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci. - Genetics (2018) · Hoffmann TJ, Choquet H, Yin J, Banda Y, Kvale MN, Glymour M, Schaefer C, Risch N, Jorgenson E · PubMed 30108127
Body mass index (BMI), a proxy measure for obesity, is determined by both environmental (including ethnicity, age, and sex) and genetic factors, with > 400 BMI-associated loci identified to date. However, the impact, interplay, and underlying biological mechanisms among BMI, environment, genetics, and ancestry are not completely understood. To further examine these relationships, we utilized 427,509 calendar year-averaged BMI measurements from 100,418 adults from the single large multiethnic Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. We observed substantial independent ancestry and nationality differences, including ancestry principal component interactions and nonlinear effects. To increase the list of BMI-associated variants before assessing other differences,
-
A Genomics England haplotype reference panel and imputation of UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 39134668
ABSTRACT: We built a reference panel with 342 million autosomal variants using 78,195 individuals from the Genomics England (GEL) dataset, achieving a phasing switch error rate of 0.18% for European samples and imputation quality of r2 = 0.75 for variants with minor allele frequencies as low as 2 × 10−4 in white British samples. The GEL-imputed UK Biobank genome-wide association analysis identified 70% of associations found by direct exome sequencing (P < 2.18 × 10−11), while extending testing of rare variants to the entire genome. Coding variants dominated the rare-variant genome-wide association results, implying less disruptive effects of rare non-coding variants. A Genomics England haplotype reference panel constructed using sequence data from 78,195 individuals
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
-
weight management and metabolic health Moderate
MAP2K5 variants associated with increased body mass index in large population cohorts, suggesting predisposition to modest weight gain.
Annual assessment of BMI and waist circumference; consider dietary intake and physical activity logging if BMI trend upward
Screening
-
blood pressure screening Moderate
MAP2K5 variants associated with increased diastolic blood pressure in large population studies; eQTL signals in cardiovascular tissues suggest tissue-specific effects.
Annual blood pressure check; baseline at next visit if not recent; discuss 24-hour ambulatory BP monitoring if elevated readings detected