rs11636802 - MNS1 - ZNF280D

Magnitude 2.8 · 1 study on file

Reported associations

• Genome-wide Association Study Identifies Multiple Risk Loci for Chronic Lymphocytic Leukemia - Unknown journal (n.d.) · Unknown authors · PubMed 23770605

  [INTRO] Despite limited discovery stages (<1,125 cases), genome-wide association studies (GWAS) have successfully identified 13 loci associated with risk of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis, to date, including four GWAS totaling 3,100 CLL cases and 7,667 controls with genotype data. In the meta-analysis, we discovered ten independent SNPs in nine novel loci at 10q23.31 (ACTA2/FAS; P=1.22×10−14), 18q21.33 (BCL2; P=7.76×10−11), 11p15.5 (C11orf21; P=2.15×10−10), 4q25 (LEF1; P=4.24×10−10), 2q33.1 (CASP10/CASP8; P=2.50×10−9), 9p21.3 (CDKN2B-AS1; P=1.27×10−8), 18q21.32 (PMAIP1; P=2.51×10−8), 15q15.1 (BMF; P=2.71×10−10), and 2p22.2 (QPCT; P=1.68×10−8) as

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