rs11636434 - SLCO3A1
Magnitude 2.2 · 1 study on file
Reported associations
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A genome‐wide association meta‐analysis of all‐cause and vascular dementia - Unknown journal (n.d.) · Unknown authors · PubMed 39046104
ABSTRACT: Abstract INTRODUCTION Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome‐wide association studies (GWAS) focus on AD. METHODS We conducted a GWAS of all‐cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors. RESULTS For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonanc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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personalized dementia prevention strategy Moderate
Carriers of SLCO3A1 rs11636434 A allele have increased dementia risk, warranting proactive discussion of evidence-based prevention approaches
Contact primary care or neurology to discuss dementia risk assessment and personalized prevention plan
Screening
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cognitive assessment for dementia risk Moderate
SLCO3A1 rs11636434 A allele carrier status is associated with increased dementia risk in large population GWAS
Discuss baseline cognitive screening with primary care provider; may begin at age 50-60