Expressive

rs11635491 - ALDH1A2, LIPC

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide characterization of circulating metabolic biomarkers - Unknown journal (n.d.) · Unknown authors · PubMed 38448586

    ABSTRACT: Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases. Here we present a genome-wide association study for 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up to 136,016 participants from 33 cohorts. We identify more than 400 independent loci and assign probable causal genes at two-thirds of these using manual curation of plausible biological candidates. We highlight the importance of sample and participant characteristics that can have significant effects on genetic associa

  • Multi-stage metabolomics and genetic analyses identified metabolite biomarkers of metabolic syndrome and their genetic determinants - Unknown journal (n.d.) · Unknown authors · PubMed 34801968

    ABSTRACT: Background Metabolic syndrome (MetS) is a cluster of multiple cardiometabolic risk factors that increase the risk of type 2 diabetes and cardiovascular diseases. Identifying novel biomarkers of MetS and their genetic associations could provide insights into the mechanisms of cardiometabolic diseases. Methods Potential MetS-associated metabolites were screened and internally validated by untargeted metabolomics analyses among 693 patients with MetS and 705 controls. External validation was conducted using two well-established targeted metabolomic methods among 149 patients with MetS and 253 controls. The genetic associations of metabolites were determined by linear regression using our previous genome-wide SNP data. Causal relationships were assessed using a one-sample Mendelian R

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • fasting glucose and insulin resistance Moderate

    rs11635491 elevates LysoPC(15:0), which causally increases insulin resistance and hyperglycemia risk

    annual fasting glucose; consider HOMA-IR assessment if overweight or diabetic family history

  • fasting triglycerides Moderate

    rs11635491 increases LysoPC(15:0) levels, which causally elevate serum triglycerides and dyslipidemia risk

    annual fasting triglyceride measurement; target <150 mg/dL

Discuss with your doctor

  • metabolic syndrome risk and screening plan Moderate

    rs11635491 in LIPC significantly increases circulating LysoPC(15:0), a metabolite causally linked to metabolic syndrome and cardiometabolic disease risk

    schedule preventive care visit to establish personalized metabolic risk assessment and monitoring strategy

Screening

  • weight and blood pressure Moderate

    rs11635491-associated LysoPC(15:0) elevation causally increases obesity and hypertension risk

    annual BMI and blood pressure measurement; target BMI <25, BP <140/90