rs116353692 - HLA-DRB9 - HLA-DRB5

Magnitude 2.2 · 3 studies on file

Reported associations

• Genome-wide association studies reveal new insights into the genetic basis of IgG4-related disease in the Chinese Han population. - Annals of the rheumatic diseases (2026) · Yan S, Peng Y, Xu J, Liu Y, Li Z, Yang Y, Peng L, Zhou J, Li L, Liu C, Chen H, Wang M, Wu Z, Zhang S, Xu H, Li H, Feng F, Fei Y, Chen Y, Dong L, Li M, Li Z, Zhang F, Zuo X, Zhang W, Li Y · PubMed 41298177

  IgG4-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder of unknown aetiology, potentially linked to genetic factors. This study conducted the first genome-wide association study on IgG4-RD in the Chinese Han population to identify genetic susceptibility loci. The study analysed data from 1161 patients with IgG4-RD and 10,539 controls across 2 independent cohorts, with 1115 patients and 10,154 controls passing quality control criteria. Using the Han-MHC reference dataset of the Chinese Han population, IgG4-RD genotyping data were imputed for the human leukocyte antigen (HLA) locus. Additionally, the study assessed the association between genetic variants and clinical characteristics, including disease activity, subtype classification, and relapse. We identified 22 si

• A cross-population atlas of genetic associations for 220 human phenotypes. - Nature genetics (2021) · Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A, Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y · PubMed 34594039

  Current genome-wide association studies do not yet capture sufficient diversity in populations and scope of phenotypes. To expand an atlas of genetic associations in non-European populations, we conducted 220 deep-phenotype genome-wide association studies (diseases, biomarkers and medication usage) in BioBank Japan (n = 179,000), by incorporating past medical history and text-mining of electronic medical records. Meta-analyses with the UK Biobank and FinnGen (n = 628,000) identified ~5,000 new loci, which improved the resolution of the genomic map of human traits. This atlas elucidated the landscape of pleiotropy as represented by the major histocompatibility complex locus, where we conducted HLA fine-mapping. Finally, we performed statistical decomposition of matrices of phenome-wid

• A genome-wide association study for allergen component sensitizations identifies allergen component-specific and allergen protein group-specific associations - Unknown journal (n.d.) · Unknown authors · PubMed 37780799

  ABSTRACT: Background Allergic diseases are some of the most common diseases worldwide. Genome-wide association studies (GWASs) have been conducted to elucidate the genetic factors of allergic diseases. However, no GWASs for allergen component sensitization have been performed. Objective We sought to detect genetic variants associated with differences in immune responsiveness against allergen components. Methods The participants of the present study were recruited from the Tokyo Children's Health, Illness, and Development study, and allergen component-specific IgE level at age 9 years was measured by means of allergen microarray immunoassays. We performed GWASs for allergen component sensitization against each allergen (single allergen component sensitization, number of allergen compone

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