Expressive

rs11635145 - SMAD3

Magnitude 2.2 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Core and lumbar spine stabilization exercises Moderate

    SMAD3-associated stenosis risk is mitigated by strong paraspinal and core musculature, which reduces abnormal spinal biomechanics and loading

    30-45 minutes core-focused exercise 3-4 times weekly

Lifestyle

  • Maintain healthy body weight for spinal health Moderate

    Elevated BMI increases compressive forces on the spine, exacerbating stenosis risk in SMAD3 variant carriers

    Target BMI 18.5-24.9 kg/m2 via balanced diet and regular activity

Screening

  • Baseline spinal imaging or clinical assessment for stenosis Moderate

    SMAD3 variants confer significant increased risk for spinal stenosis development (GWAS p=1e-22, n=427948, effect size=0.068)

    Discuss with physician whether baseline imaging or clinical assessment is warranted given genotype and individual risk factors