rs11634543 - CHRNB4
Magnitude 2.2 · 1 study on file
Reported associations
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A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 26634245
ABSTRACT: Background Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed a genome-wide association study (GWAS) in 9919 current and former smokers in the COPDGene study (6659 non-Hispanic Whites [NHW] and 3260 African Americans [AA]) to identify associations with spirometric measures (post-bronchodilator FEV1 and FEV1/FVC). We also conducted meta-analysis of FEV1 and FEV1/FVC GWAS in the COPDGene, ECLIPSE, and GenKOLS cohorts (total n = 13,532). Results Among NHW in the COPDGene cohort, both measures of pulmonary function were significantly associated with SNPs at the 15q25 locus [containing CHRNA3/5, AGPHD1, IREB2, CHRNB4] (low
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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respiratory function risk and preventive strategies Moderate
genetic association with lower FEV1 indicates need for individualized respiratory health plan
discuss baseline lung function testing and risk reduction strategies with healthcare provider
Lifestyle
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smoking and secondhand smoke Moderate
CHRNB4 variant reduces baseline FEV1; smoking further impairs respiratory function
abstain from smoking; minimize secondhand smoke exposure
Screening
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baseline spirometry Moderate
CHRNB4 T-allele associated with lower post-bronchodilator FEV1, indicating reduced lung capacity
perform at age 30-40 or sooner if symptoms; repeat per provider guidance