Expressive

rs11634109 - NEIL1

Magnitude 2.2 · 1 study on file

Reported associations

  • Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank. - Osteoarthritis and cartilage (2023) · Hollis B, Chatzigeorgiou C, Southam L, Hatzikotoulas K, Kluzek S, Williams A, Zeggini E, Jostins-Dean L, Watt FE · PubMed 37247657

    Acute knee injury is associated with post-traumatic OA (PTOA). Very little is known about the genome-wide associations of PTOA when compared with idiopathic OA (iOA). Our objective was to describe the development of knee OA after a knee injury and its genetic associations in UK Biobank (UKB). Clinically significant structural knee injuries in those ≤50 years were identified from electronic health records and self-reported data in 502,409 UKB participants. Time-to-first knee osteoarthritis (OA) code was compared in injured cases and age-/sex-matched non-injured controls using Cox Proportional Hazards models. A time-to-OA genome-wide association study (GWAS) sought evidence for PTOA risk variants 6 months to 20 years following injury. Evidence for associations of two iOA polygenic risk sco

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Regular low-impact joint-protective exercise Moderate

    Weight-bearing exercise strengthens periarticular muscles and maintains joint stability, reducing osteoarthritis progression risk.

    150 min/week moderate-intensity activity (swimming, cycling, elliptical); strength training 2x/week

Lifestyle

  • Maintain healthy body weight Moderate

    Excess weight increases mechanical load on knee joints; weight management is critical for those with genetic predisposition to osteoarthritis.

    Target BMI less than 25; discuss sustainable weight management strategies with healthcare provider if overweight

Screening

  • Knee osteoarthritis clinical and imaging screening Moderate

    rs11634109 C allele carriers have 1.04-fold increased risk for idiopathic knee osteoarthritis; early detection allows preventive intervention.

    Baseline assessment at age 40, repeat imaging if symptoms develop