Expressive

rs11633958 - CHRNA5

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-Wide Association Study of Nicotine Dependence in American Populations: Identification of Novel Risk Loci in Both African-Americans and European-Americans - Unknown journal (n.d.) · Unknown authors · PubMed 25555482

    ABSTRACT: BACKGROUND We report a genome-wide association study (GWAS) of nicotine dependence defined on the basis of scores on the Fagerström Test for Nicotine Dependence in European-American (EA) and African-American (AA) populations. METHODS Our sample, from the one used in our previous GWAS, included only subjects who had smoked >100 cigarettes lifetime (2114 EA and 2602 AA subjects) and an additional 927 AA and 2003 EA subjects from the Study of Addiction: Genetics and Environment project [via the database of Genotypes and Phenotypes (dbGAP)]. GWAS analysis considered Fagerström Test for Nicotine Dependence score as an ordinal trait, separately in each population and sample and by combining the results in meta-analysis. We also conducted analyses that were adjusted for other substanc

  • A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry - Unknown journal (n.d.) · Unknown authors · PubMed 26634245

    ABSTRACT: Background Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed a genome-wide association study (GWAS) in 9919 current and former smokers in the COPDGene study (6659 non-Hispanic Whites [NHW] and 3260 African Americans [AA]) to identify associations with spirometric measures (post-bronchodilator FEV1 and FEV1/FVC). We also conducted meta-analysis of FEV1 and FEV1/FVC GWAS in the COPDGene, ECLIPSE, and GenKOLS cohorts (total n = 13,532). Results Among NHW in the COPDGene cohort, both measures of pulmonary function were significantly associated with SNPs at the 15q25 locus [containing CHRNA3/5, AGPHD1, IREB2, CHRNB4] (low

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic predisposition to dependence and low lung function Moderate

    CHRNA5 variant substantially increases risk for nicotine dependence and lower FEV1.

    Review genetic findings, smoking status, and preventive strategies with healthcare provider.

Lifestyle

  • tobacco smoking High

    Genetic predisposition to nicotine dependence and impaired lung function compounds respiratory disease risk.

    Never initiate; if currently smoking, pursue cessation via counseling or pharmacotherapy.

  • prolonged air pollution exposure Moderate

    Compromised baseline lung function increases vulnerability to respiratory damage from inhaled pollutants.

    Minimize high pollution exposure; avoid secondhand smoke and occupational respiratory irritants.

Screening

  • lung function with spirometry High

    CHRNA5 variant associated with reduced FEV1, a marker of respiratory disease risk.

    Baseline spirometry by age 30-40; repeat every 2-3 years per provider guidance.