rs116335247 - RN7SL201P - LYARP1
Magnitude 4.5 · 1 study on file
Reported associations
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Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits - Unknown journal (n.d.) · Unknown authors · PubMed 34734193
ABSTRACT: Summary Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from five ancestry groups. In the combined meta-analyses of stages 1 and 2, we identified 59 loci (p value < 5e−8), including nine novel BP loci. The novel associations were observed mostly with pulse pressure, with fewer observed with mean arterial pressure. Five
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Social support and stress management Moderate
Genetic effect on blood pressure is modified by social support status, indicating modifiable cofactor relevance
Maintain social connections, engage community activities, practice stress reduction techniques
Screening
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Blood pressure assessment Moderate
Variant shows significant interaction with social support on systolic blood pressure in large GWAS cohort
Annual blood pressure screening starting in adulthood