rs11633223 - CHRNB4

Magnitude 2.0 · 1 study on file

Reported associations

• A Prospective Analysis of Genetic Variants Associated with Human Lifespan - G3 (Bethesda, Md.) (2020) · Wright KM, Rand KA, Kermany A, Noto K, Curtis D, Garrigan D, Slinkov D, Dorfman I, Granka JM, Byrnes J, Myres N, Ball CA, Ruby JG · PubMed 31484785

  ABSTRACT: We present a massive investigation into the genetic basis of human lifespan. Beginning with a genome-wide association (GWA) study using a de-identified snapshot of the unique AncestryDNA database - more than 300,000 genotyped individuals linked to pedigrees of over 400,000,000 people - we mapped six genome-wide significant loci associated with parental lifespan. We compared these results to a GWA analysis of the traditional lifespan proxy trait, age, and found only one locus, APOE, to be associated with both age and lifespan. By combining the AncestryDNA results with those of an independent UK Biobank dataset, we conducted a meta-analysis of more than 650,000 individuals and identified fifteen parental lifespan-associated loci. Beyond just those significant loci, our genome-w

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.