Expressive

rs11632096 - NEDD4

Magnitude 2.2 · 2 studies on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

  • Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations - Unknown journal (n.d.) · Unknown authors · PubMed 40835838

    ABSTRACT: Keloids are raised scars that grow beyond original wound boundaries, resulting in pain and disfigurement. Reasons for keloid development are not well-understood, and current treatment options are limited. Keloids are more likely to occur in darker-skinned individuals of African and Asian descent than in Europeans. We performed a genome-wide association study (GWAS) examining keloid risk across and within continental ancestry groups, incorporating 7837 cases and 1,593,009 controls. We detected 26 loci in the multi-ancestry analysis, 12 of which replicated in an independent dataset. Heritability estimates were 6%, 21%, and 34% for the European, East Asian, and African ancestry analyses, respectively. Genetically predicted gene expression and colocalization analyses identified 27 ge

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • keloid risk with dermatologist before surgery Moderate

    NEDD4 variants significantly increase keloid formation after surgical trauma; pre-operative dermatology assessment enables preventive strategies

    consult dermatologist before any elective surgery or invasive procedure

Lifestyle

  • unnecessary skin trauma and elective procedures Moderate

    NEDD4 risk variants increase fibroblast responsiveness to wound signals, increasing keloid formation risk; minimizing trauma reduces triggers

    avoid piercings, tattoos, and elective surgery unless medically necessary

Screening

  • monitor for keloid formation Moderate

    NEDD4 variants strongly associated with keloid susceptibility; early detection enables prompt treatment with established therapies