rs11631816 - HCN4
Magnitude 2.8 · 1 study on file
Reported associations
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Identification of susceptibility loci for cardiovascular disease in adults with hypertension, diabetes, and dyslipidemia - Unknown journal (n.d.) · Unknown authors · PubMed 33632238
ABSTRACT: Background Hypertension (HTN), diabetes mellitus (DM), and dyslipidemia (DL) are well-known risk factors of cardiovascular disease (CVD), but not all patients develop CVDs. Studies have been limited investigating genetic risk of CVDs specific to individuals with metabolic diseases. This study aimed to identify disease-specific and/or common genetic loci associated with CVD susceptibility in chronic metabolic disease patients. Methods We conducted a genome-wide association study (GWAS) of a multiple case-control design with data from the City Cohort within Health EXAminees subcohort of the Korean Genome and Epidemiology Study (KoGES_HEXA). KoGES_HEXA is a population-based prospective cohort of 173,357 urban Korean adults that had health examinations at medical centers. 42,393 pa
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Heart-healthy lipid management diet Moderate
GWAS association specific to dyslipidemia context; diet influences CAD risk
Emphasize unsaturated fats, reduce refined carbs, increase fiber
Discuss with your doctor
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CAD prevention strategy and screening protocol Moderate
Moderate evidence warrants personalized prevention approach
Lifestyle
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Cardiovascular health optimization Moderate
HCN4 regulates cardiac pacemaker function; cardiovascular fitness reduces CAD risk
Moderate-intensity aerobic exercise 150 min/week, stress management
Screening
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Coronary artery disease risk assessment Moderate
HCN4 variant increases CAD risk 1.43x per A allele in dyslipidemic individuals
Baseline assessment and periodic monitoring