rs116315540 - SAMD4B

Magnitude 2.0 · 1 study on file

Reported associations

• Genetic regulators of cytokine responses upon BCG vaccination in children from West Africa. - Journal of genetics and genomics = Yi chuan xue bao (2023) · Boahen CK, Moorlag SJCFM, Jensen KJ, Matzaraki V, Fanucchi S, Monteiro I, de Bree C, Fok ET, Mhlanga M, Joosten LAB, Aaby P, Benn CS, Netea MG, Kumar V · PubMed 36681271

  Genetic variation is a key factor influencing cytokine production capacity, but which genetic loci regulate cytokine production before and after vaccination, particularly in African population is unknown. Here, we aimed to identify single-nucleotide polymorphisms (SNPs) controlling cytokine responses after microbial stimulation in infants of West-African ancestry, comprising of low-birth-weight neonates randomized to bacillus Calmette-Guérin (BCG) vaccine-at-birth or to the usual delayed BCG. Genome-wide cytokine cytokine quantitative trait loci (cQTL) mapping revealed 12 independent loci, of which the LINC01082-LINC00917 locus influenced more than half of the cytokine-stimulation pairs assessed. Furthermore, nine distinct cQTLs were found among infants randomized to BCG. Functional valid

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.