rs11630851 - DNM1P35
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study of periodontal pocketing in Finnish adults - Unknown journal (n.d.) · Unknown authors · PubMed 34847907
ABSTRACT: Background A genome‐wide association study is an analytical approach that investigates whether genetic variants across the whole genome contribute to disease progression. The aim of this study was to investigate genome-wide associations of periodontal condition measured as deepened periodontal pockets (≥ 4 mm) in Finnish adults. Methods This study was based on the data of the national Health 2000 Survey (BRIF8901) in Finland and the Northern Finland Birth Cohort 1966 Study totalling 3,245 individuals. The genotype data were analyzed using the SNPTEST v.2.4.1. The number of teeth with deepened periodontal pockets (≥ 4 mm deep) was employed as a continuous response variable in additive regression analyses performed separately for the two studies and the results were com
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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enhanced plaque control regimen Moderate
The GWAS adjusted for dental plaque as a major modifiable risk factor; more rigorous plaque control may offset genetic predisposition to periodontal pockets
Twice-daily brushing, daily interdental cleaning (floss or picks), consider professional cleaning at 6-month intervals
Screening
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periodontal pocket depth screening Moderate
rs11630851 T allele is associated with increased periodontal pocket depth (beta=0.30, p=9.39e-7), indicating elevated baseline periodontal disease risk
Annual periodontal examination; baseline assessment if not completed within past 2 years