rs116298963 - HLA-Z - HLA-DMB
Magnitude 2.2 · 1 study on file
Reported associations
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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes - Unknown journal (n.d.) · Unknown authors · PubMed 28604730
ABSTRACT: Summary While several lung cancer susceptibility loci have been identified, much of lung cancer heritability remains unexplained. Here, 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated GWAS analysis of lung cancer on 29,266 patients and 56,450 controls. We identified 18 susceptibility loci achieving genome wide significance, including 10 novel loci. The novel loci highlighted the striking heterogeneity in genetic susceptibility across lung cancer histological subtypes, with four loci associated with lung cancer overall and six with lung adenocarcinoma. Gene expression quantitative trait analysis (eQTL) in 1,425 normal lung tissues highlighted RNASET2, SECISBP2L and NRG1 as candidate genes. Other
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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tobacco smoke exposure Moderate
Genetic predisposition to lung cancer is substantially elevated by smoking; avoiding tobacco is critical risk mitigation
Do not smoke; minimize secondhand smoke exposure
Screening
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lung cancer screening strategy Moderate
HLA-DMB variant (rs116298963, G allele) associated with increased lung cancer risk (1.119-fold per allele)
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respiratory symptoms and lung function Moderate
Elevated genetic lung cancer risk warrants heightened awareness of respiratory changes
Report any persistent cough, chest pain, or dyspnea to healthcare provider immediately