Expressive

rs11629531 - ALPK3 - SLC28A1

Magnitude 2.2 · 1 study on file

Reported associations

  • GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer - Unknown journal (n.d.) · Unknown authors · PubMed 34021172

    ABSTRACT: Genetic studies have examined body-shape measures adjusted for body mass index (BMI), while allometric indices are additionally adjusted for height. We performed the first genome-wide association study of A Body Shape Index (ABSI), Hip Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using data from the UK Biobank Resource for 219,872 women and 186,825 men with white British ancestry and Bayesian linear mixed-models (BOLT-LMM). One to two thirds of the loci identified for allometric body-shape indices were novel. Most prominent was rs72959041 variant in RSPO3 gene, expressed in visceral adipose tissue and regulating adrenal cell renewal. Highly ranked were genes related to morphogenesis and organogenesis, previously additionally linked to can

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Structured exercise targeting visceral adiposity Moderate

    Aerobic and resistance training preferentially reduce central fat deposition, partially offsetting genetic predisposition to elevated WHR

    150 min moderate-intensity aerobic activity plus 2 sessions/week resistance training

Screening

  • Metabolic syndrome and glucose homeostasis screening Moderate

    Elevated waist-hip ratio associates with insulin resistance, dyslipidemia, and hypertension; proactive screening warranted for carriers

    Fasting glucose, HbA1c, lipid panel, blood pressure assessment every 1-2 years

  • Waist-hip ratio and abdominal circumference Moderate

    T allele carriers show increased waist-hip ratio, a marker of central adiposity and metabolic risk independent of BMI

    Annual measurement; target WHR <0.85 for women, <0.95 for men; abdominal circumference <40 inches men, <35 inches women