rs11628653 - RAD51B
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Dark leafy greens for lutein and zeaxanthin Moderate
Carotenoid antioxidants concentrate in retinal tissue and provide protective effects against oxidative damage in macular degeneration
Consume spinach, kale, or collards 3-4 times weekly; aim for 1-2 cups per serving
Lifestyle
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UV protective eyewear during outdoor exposure Moderate
Cumulative ultraviolet exposure damages retinal cells and accelerates age-related macular degeneration development
Wear sunglasses offering 100% UVA and UVB protection for outdoor activity beyond 30 minutes
Screening
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Regular comprehensive eye examination for macular health Moderate
Genetic variants in RAD51B increase susceptibility to age-related macular degeneration; early detection enables monitoring and preventive management
Schedule dilated eye exam with ophthalmologist; baseline before age 55, repeat every 1-2 years