Expressive

rs11627050 - HMGB3P26 - RPSAP5

Magnitude 2.2 · 1 study on file

Reported associations

  • Translational genomics of osteoarthritis in 1,962,069 individuals - Unknown journal (n.d.) · Unknown authors · PubMed 40205036

    ABSTRACT: Osteoarthritis is the third most rapidly growing health condition associated with disability, after dementia and diabetes. By 2050, the total number of patients with osteoarthritis is estimated to reach 1 billion worldwide. As no disease-modifying treatments exist for osteoarthritis, a better understanding of disease aetiopathology is urgently needed. Here we perform a genome-wide association study meta-analyses across up to 489,975 cases and 1,472,094 controls, establishing 962 independent associations, 513 of which have not been previously reported. Using single-cell multiomics data, we identify signal enrichment in embryonic skeletal development pathways. We integrate orthogonal lines of evidence, including transcriptome, proteome and epigenome profiles of primary joint tiss

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Osteoarthritis risk and prevention strategies Moderate

    Genetic variant rs11627050 confers increased osteoarthritis risk; physician guidance optimizes prevention

    • GWAS_CATALOG:40205036

Exercise

  • Low-impact joint-protective exercise Moderate

    Appropriate exercise strengthens supporting musculature and protects joints genetically predisposed to osteoarthritis

    Emphasize swimming, cycling, or resistance training; minimize high-impact activities

    • GWAS_CATALOG:40205036

Lifestyle

  • Weight management for joint health Moderate

    Maintaining healthy weight reduces mechanical burden on joints affected by genetic osteoarthritis risk

    Monitor weight; discuss with physician if overweight

    • GWAS_CATALOG:40205036

Screening

  • Osteoarthritis screening for genetic risk Moderate

    rs11627050 strongly associated with increased osteoarthritis risk and total knee replacement

    Discuss with physician about baseline knee assessment and monitoring plan

    • GWAS_CATALOG:40205036