rs11626768 - YTHDF2P1 - MIA2
Magnitude 2.2 · 1 study on file
Reported associations
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The power of genetic diversity in genome-wide association studies of lipids - Unknown journal (n.d.) · Unknown authors · PubMed 34887591
ABSTRACT: Elevated blood lipid levels are heritable risk factors of cardiovascular disease with varying prevalence worldwide due to differing dietary patterns and medication use. Despite advances in prevention and treatment, particularly through the lowering of low-density lipoprotein cholesterol levels, heart disease remains the leading cause of death worldwide. Genome-wide association studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS have been conducted in European ancestry populations and may have missed genetic variants contributing to lipid level variation in other ancestry groups due to differences in allele frequencies, effect sizes, and linkage-disequilibr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Lipid panel screening High
rs11626768 A allele is strongly associated with elevated total cholesterol levels
Baseline lipid panel; repeat every 5 years or per physician recommendation
Discuss with your doctor
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Cholesterol status and cardiovascular risk management Moderate
Carriers have genetic predisposition to elevated total cholesterol levels