Expressive

rs116262938 - TRMT44

Magnitude 2.2 · 1 study on file

Reported associations

  • GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network - Unknown journal (n.d.) · Unknown authors · PubMed 31311600

    ABSTRACT: Background Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver illness with a genetically heterogeneous background that can be accompanied by considerable morbidity and attendant health care costs. The pathogenesis and progression of NAFLD is complex with many unanswered questions. We conducted genome-wide association studies (GWASs) using both adult and pediatric participants from the Electronic Medical Records and Genomics (eMERGE) Network to identify novel genetic contributors to this condition. Methods First, a natural language processing (NLP) algorithm was developed, tested, and deployed at each site to identify 1106 NAFLD cases and 8571 controls and histological data from liver tissue in 235 available participants. These include 1242 pediatric participants

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Alanine aminotransferase (ALT) levels Moderate

    rs116262938 T allele is associated with elevated ALT in non-alcoholic fatty liver disease

    Check ALT levels annually or per doctor recommendation

Discuss with your doctor

  • NAFLD risk and ALT monitoring strategy Moderate

    Genetic variant associated with elevated liver enzymes in NAFLD warrants discussion of screening and monitoring approach

Lifestyle

  • Maintain healthy weight and regular physical activity Moderate

    Lifestyle modifications reduce liver fat accumulation and ALT elevation in NAFLD

    Aim for 30 minutes of moderate activity most days