rs116262092 - RUNX1

Magnitude 2.2 · 1 study on file

Reported associations

• A GWAS Meta-Analysis of Stroke in 22,000 individuals of African descent identifies novel associations with stroke - Unknown journal (n.d.) · Unknown authors · PubMed 32693751

  ABSTRACT: Background and Purpose Stroke is a complex disease with multiple genetic and environmental risk factors. African Americans endure a nearly two-fold greater risk of stroke and are 2-3 times more likely to die from stroke than European Americans. Methods The Consortium of Minority Population genome-wide Association Studies of Stroke (COMPASS) has conducted a genome-wide association meta-analysis of stroke in more than 22,000 individuals of African ancestry (3,734 cases, 18,317 controls) from 13 cohorts. Results In meta-analyses, we identified one SNP (rs55931441) near the HNF1A gene that reached genome-wide significance (P = 4.62×10−8) and an additional 29 variants with suggestive evidence of association (P < 1×10−6), representing 24 unique loci. For validation, a look-up a

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