rs11625461 - GNG2
Magnitude 4.5 · 1 study on file
Reported associations
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A genome-wide association study of chronic obstructive pulmonary disease in Hispanics. - Annals of the American Thoracic Society (2015) · Chen W, Brehm JM, Manichaikul A, Cho MH, Boutaoui N, Yan Q, Burkart KM, Enright PL, Rotter JI, Petersen H, Leng S, Obeidat M, Bossé Y, Brandsma CA, Hao K, Rich SS, Powell R, Avila L, Soto-Quiros M, Silverman EK, Tesfaigzi Y, Barr RG, Celedón JC · PubMed 25584925
Genome-wide association studies (GWAS) of chronic obstructive pulmonary disease (COPD) have identified disease-susceptibility loci, mostly in subjects of European descent. We hypothesized that by studying Hispanic populations we would be able to identify unique loci that contribute to COPD pathogenesis in Hispanics but remain undetected in GWAS of non-Hispanic populations. We conducted a metaanalysis of two GWAS of COPD in independent cohorts of Hispanics in Costa Rica and the United States (Multi-Ethnic Study of Atherosclerosis [MESA]). We performed a replication study of the top single-nucleotide polymorphisms in an independent Hispanic cohort in New Mexico (the Lovelace Smokers Cohort). We also attempted to replicate prior findings from genome-wide studies in non-Hispanic populations in
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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COPD genetic risk assessment and baseline spirometry Moderate
rs11625461 C allele is associated with increased COPD susceptibility; baseline lung function establishes individual risk trajectory.
Discuss with primary care provider about baseline spirometry screening.
Lifestyle
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Smoking and secondhand smoke exposure Moderate
Smoking is the primary modifiable COPD risk factor; C allele carriers with genetic predisposition should prioritize avoidance.
Avoid active and passive smoking; minimize occupational and environmental respiratory irritant exposure.