rs116211928 - ZNF77 - TLE6

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of early ischemic stroke risk in Brazilian Individuals with Sickle Cell Disease implicates ADAMTS2, CDK18 and uncovers novel loci - Unknown journal (n.d.) · Unknown authors · PubMed 36602125

  ABSTRACT: Ischemic stroke is a common complication of sickle cell disease (SCD) and without intervention can affect 11% of children with SCD before the age of 20. Within the Trans-Omics for Precision Medicine (TOPMed), a genome-wide association study (GWAS) of ischemic stroke was performed on 1,333 individuals with SCD from Brazil (178 cases, 1,155 controls). Via a novel Cox proportional hazards analysis, we searched for variants associated with ischemic stroke occurring at younger ages. Variants at genome wide significance (P<5×10−8) include two near genes previously linked to non-SCD early onset stroke (<65 years): ADAMTS2 (rs147625068, P=3.70 × 10−9) and CDK18 (rs12144136, P=2.38 × 10−9). Meta-analysis which included the independent SCD cohorts Walk-PHaSST and PUSH exhibited co

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