Expressive

rs11620731 - COX16, SYNJ2BP-COX16

Magnitude 2.2 · 1 study on file

Reported associations

  • A large electronic health record-based genome-wide study of serum lipids - Unknown journal (n.d.) · Unknown authors · PubMed 29507422

    ABSTRACT: A genome-wide association study of 94,674 multi-ethnic Kaiser Permanente members utilizing 478,866 longitudinal untreated serum lipid electronic-health-record-derived measurements (EHRs) empowered multiple novel findings: 121 new SNP associations (46 primary, 15 conditional, 60 in meta-analysis with Global Lipids Genetic Consortium); increase of 33-42% in variance explained with multiple measurements; sex differences in genetic impact (greater in females for LDL, HDL, TC, the opposite for TG); differences in variance explained amongst non-Hispanic whites, Latinos, African Americans, and East Asians; genetic dominance and epistasis, with strong evidence for both at ABOxFUT2 for LDL; and eQTL tissue-enrichment implicating the liver, adipose, and pancreas. Utilizing EHR pharmacy dat

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • lipid panel screening Moderate

    rs11620731 T allele carriers have increased LDL and total cholesterol levels, warranting regular monitoring.

    Annual lipid panel starting at age 30; more frequent screening if cholesterol is elevated.

Diet

  • Mediterranean or DASH diet Moderate

    Heart-healthy dietary patterns help manage cholesterol levels, especially important for genetically predisposed individuals.

    Emphasize whole grains, fruits, vegetables, fish, and healthy fats; limit saturated fats and processed foods.

Discuss with your doctor

  • cholesterol management strategy Moderate

    Genetic predisposition to elevated cholesterol warrants proactive management planning.

    Discuss cholesterol targets, monitoring frequency, and potential interventions with healthcare provider.

Exercise

  • regular aerobic exercise Moderate

    Aerobic exercise reduces LDL cholesterol and improves lipid profile, particularly beneficial for elevated cholesterol risk.

    150 minutes moderate-intensity aerobic activity per week, or 75 minutes high-intensity interval training.