rs11616264 - GJB6 - CRYL1

Magnitude 2.2 · 1 study on file

Reported associations

• Kallikrein augments the anticoagulant function of the protein C system in thrombin generation - Unknown journal (n.d.) · Unknown authors · PubMed 34532976

  ABSTRACT: Abstract Background Genetics play a significant role in coagulation phenotype and venous thromboembolism risk. Resistance to the anticoagulant activated protein C (APC) is an established risk for thrombosis. Herein, we explored the genetic determinants of thrombin generation (TG) and thrombomodulin (TM)‐modulated TG using plasma from the Human Functional Genomics Project. Methods Calibrated TG was measured both in absence and presence of TM using tissue factor as trigger. Genetic determinants of TG parameters and protein C pathway function were assessed using genome‐wide single‐nucleotide polymorphism (SNP) genotyping. Plasma samples were supplemented with purified apolipoprotein A‐IV, prekallikrein, or kallikrein to test their influence on the anticoagulant function of T

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