rs11615578 - CAMKK2
Magnitude 2.2 · 1 study on file
Reported associations
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New role of fat-free mass in cancer risk linked with genetic predisposition - Unknown journal (n.d.) · Unknown authors · PubMed 38538606
ABSTRACT: Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectrical impedance and BMI data was collected on ~ 500,000 individuals. Using this dataset, a comprehensive analysis using regression, principal component and genome-wide genetic association, provided multiple levels of evidence that increasing whole body fat (WBFM) and fat-free mass (WBFFM) are both associated with increased post-menopausal breast cancer risk, and colorectal cancer risk in men. WBFM was inversely associated with prostate cancer. We also identified rs615029[T] and rs1485995[G] as associated in independent analyses with both PMB
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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Regular resistance and strength training Moderate
CAMKK2 regulates AMPK signaling in skeletal muscle. The T risk allele associates with higher fat mass; strength training can offset this predisposition.
3-4 sessions per week targeting major muscle groups
Lifestyle
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Body weight and fat mass Moderate
rs11615578 T allele shows genome-wide significant association with increased whole-body fat mass (n=337,196).
Monthly weight tracking; annual body composition assessment if available