Expressive

rs116142041 - SLC2A9

Magnitude 2.2 · 1 study on file

Reported associations

  • Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484

    ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • High-purine foods (red meat, organ meats, certain shellfish) Moderate

    Dietary purines metabolize to urate; individuals with genetic predisposition benefit from reducing purine intake

    Prefer poultry and plant proteins; limit red meat to no more than 3 servings per week

  • Sugar-sweetened beverages and high-fructose foods Moderate

    Fructose metabolism increases urate production; restriction lowers serum urate independent of purine reduction

    Minimize sodas, fruit juices, and processed foods with high-fructose corn syrup

Discuss with your doctor

  • Genetic predisposition to elevated urate and prevention strategy Moderate

    Strong genetic association with serum urate warrants discussion of personalized monitoring and management approach

Lifestyle

  • Adequate daily hydration Moderate

    Increased urine output promotes renal urate excretion, reducing serum urate levels

    Aim for 2.5 to 3 liters of water daily, more if exercising or in warm climate

  • Weight management and limiting alcohol Moderate

    Obesity increases urate production; alcohol impairs renal urate excretion; both elevate serum urate

    Maintain healthy BMI 18.5-25; limit alcohol to no more than 2 drinks daily for men or 1 for women

Screening

  • Serum uric acid levels Moderate

    SLC2A9 A allele strongly associated with elevated serum urate, increasing gout and chronic kidney disease risk

    Obtain baseline serum uric acid level; recheck annually or as directed by physician