rs11613457 - ARHGEF25 - SLC26A10P
Magnitude 2.2 · 1 study on file
Reported associations
-
Genetics of 35 blood and urine biomarkers in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 33462484
ABSTRACT: Clinical laboratory tests are a critical component of the continuum of care. We evaluate the genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n=363,228 individuals). We identify 1,857 loci associated with at least one trait, containing 3,374 fine-mapped associations, and additional sets of large-effect (> 0.1 sd) protein-altering, HLA, and copy-number variant associations. Through Mendelian Randomization analysis, we discover 51 causal relationships, including previously known agonistic effects of urate on gout and cystatin C on stroke. Finally, we develop polygenic risk scores for each biomarker and built 'multi-PRS' models for diseases using 35 PRSs simultaneously, which improved chronic kidney disease, type 2 diabetes, gout, and alcoholic cirr
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
-
High-purine foods and sugar-sweetened beverages Moderate
Dietary purines increase uric acid; rs11613457 A allele elevates baseline urate, compounding dietary effects
Reduce red meat, organ meats, shellfish, beer; avoid sugar-sweetened drinks
Lifestyle
-
Hydration and weight management Moderate
Adequate hydration and healthy weight reduce uric acid levels; important for carriers of rs11613457 A allele with elevated baseline urate
Maintain hydration (2+ liters water daily); keep BMI under 25 if overweight
Screening
-
Serum urate levels Moderate
rs11613457 A allele associates with elevated serum urate, increasing gout and kidney stone risk
Baseline serum urate testing if not recent; annual monitoring for carriers