rs11611584 - KRT6A - KRT5
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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excessive sun exposure High
Genetic predisposition increases actinic keratosis risk, a sun-induced precancerous lesion; cumulative UV exposure is the primary modifiable driver.
Apply SPF 30+ daily to exposed areas, wear protective clothing, limit midday sun exposure.
Screening
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periodic dermatology screening for actinic keratosis High
Genetic predisposition significantly increases actinic keratosis risk; early detection enables timely treatment and cancer prevention.
Annual full-body skin examination by dermatologist; monthly self-skin checks for new or changing lesions.