rs116075662 - MMAA
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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dietary vitamin B12 sources Moderate
Genetic B12 malabsorption risk warrants preventive dietary focus
include animal products or fortified foods daily
Discuss with your doctor
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B12 supplementation strategy given genetic risk Moderate
MMAA variants increase B12 malabsorption; supplementation may prevent deficiency
Screening
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vitamin B12 levels Moderate
MMAA variants disrupt B12 metabolism, increasing deficiency risk
annual B12 serum testing; more frequent if symptomatic