rs116075662 - MMAA

Magnitude 2.2 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp


Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • dietary vitamin B12 sources Moderate

    Genetic B12 malabsorption risk warrants preventive dietary focus

    include animal products or fortified foods daily

Discuss with your doctor

  • B12 supplementation strategy given genetic risk Moderate

    MMAA variants increase B12 malabsorption; supplementation may prevent deficiency

Screening

  • vitamin B12 levels Moderate

    MMAA variants disrupt B12 metabolism, increasing deficiency risk

    annual B12 serum testing; more frequent if symptomatic