rs116075512 - LINC00708 - KRT8P37

Magnitude 4.5 · 1 study on file

Reported associations

• Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility. - American journal of human genetics (2025) · Betti MJ, Jaworski J, Zhao S, Rao JS, Ryan BM, Schwartz AG, Lusk CM, McCoy L, Wiencke JK, Bruce MA, Chanock S, Gamazon ER, Hellwege JN, Aldrich MC · PubMed 40829600

  Striking disparities in lung cancer exist, with Black/African American individuals disproportionately affected by lung cancer, yet the genetic architecture in African ancestry individuals is poorly understood. We aimed to address this by performing a comprehensive genetic association study of lung cancer, incorporating local ancestry, across 6,490 African ancestry individuals (2,390 individuals with lung cancer and 4,100 control subjects). We identified a single genome-wide significant (p < 5 × 10 ) locus, 15q25.1 (lead SNP rs17486278, OR [95% CI] = 1.34 [1.23-1.45], p = 4.52 × 10 ), that has consistently shown a strong association with lung cancer across populations. Additionally, we identified nine suggestive (p < 1 × 10 ) loci. Four of these loci (3p12.1, 8q22.2, 14q11.2, and 18q22.3

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