rs11606902 - ME3 - PRSS23
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma - Unknown journal (n.d.) · Unknown authors · PubMed 29785010
ABSTRACT: Glaucoma is the leading cause of irreversible blindness globally. Despite its gravity, the disease is frequently undiagnosed in the community. Raised intraocular pressure (IOP) is the most important risk factor for primary open-angle glaucoma (POAG). Here we present a meta-analysis of 139,555 European participants that identified 112 genomic loci associated with IOP, 68 of which are novel. These loci suggest a strong role for angiopoietin-receptor tyrosine kinase signaling, lipid metabolism, mitochondrial function and developmental processes underlying risk for elevated IOP. In addition, 48 of these loci were associated with glaucoma in an independent cohort, 14 of which at a Bonferroni-corrected threshold. Regression-based glaucoma prediction models had an area under Receiving O
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to elevated intraocular pressure Moderate
Understanding this genetic risk factor helps ophthalmologists tailor prevention and monitoring strategies for glaucoma.
Discuss this genetic finding with your eye care provider at your next visit
Screening
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intraocular pressure monitoring for glaucoma risk Moderate
This SNP is strongly associated with elevated intraocular pressure, a major risk factor for glaucoma development and vision loss.
Annual or bi-annual intraocular pressure measurement and optic nerve assessment starting at age 30-40