rs11602769 - CFL1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis - Unknown journal (n.d.) · Unknown authors · PubMed 30013184
[INTRO] Introduction [INTRO] Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, and with increasing incidence in westernized countries. To elucidate the genetic architecture and understand disease mechanisms of allergic rhinitis, we carried out a metaanalysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implied genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants of importance for antigen binding. We further perf
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Discuss allergic sensitization risk from CFL1 variant Moderate
GWAS evidence shows C allele increases allergic sensitization risk
Review family history and develop risk management strategy
Screening
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Allergy testing to establish baseline sensitization Moderate
CFL1 C allele associated with increased allergic sensitization risk
Discuss comprehensive allergy testing with healthcare provider
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Monitor for development of allergic symptoms Moderate
Genetic predisposition increases likelihood of allergic responses
Track and report allergic symptoms to healthcare provider regularly