rs11602337 - LUZP2 - RPL36AP40
Magnitude 2.2 · 1 study on file
Reported associations
-
Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias - Unknown journal (n.d.) · Unknown authors · PubMed 25188341
ABSTRACT: Alzheimer's disease (AD) and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight into molecular pathogenesis. We performed a genome-wide association study and analysis of known genetic risk loci for AD dementia using neuropathologic data from 4,914 brain autopsies. Neuropathologic data were used to define clinico-pathologic AD dementia or controls, assess core neuropathologic features of AD (neuritic plaques, NPs; neurofibrillary tangles, NFTs), and evaluate commonly co-morbid neuropathologic changes: cerebral amyloid angiopathy (CAA), Lewy body disease (LBD), hippocampal sclerosis of the elderly (HS), and vascular brain injury (VBI). Genome-wide significance was observed for clinico-pathologic AD dementi
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
Vascular disease risk management strategy Moderate
Genetic association with vascular brain injury indicates elevated personal vascular disease risk warranting preventive strategy
Exercise
-
Aerobic cardiovascular exercise Moderate
Aerobic exercise reduces blood pressure and improves vascular endothelial function, lowering vascular disease risk
150 minutes moderate intensity per week or equivalent
Screening
-
Blood pressure screening Moderate
Hypertension is the primary modifiable risk factor for cerebrovascular disease and vascular brain injury
Annual screening minimum, earlier if hypertensive