rs11601602 - METTL15
Magnitude 2.2 · 1 study on file
Reported associations
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Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population - Unknown journal (n.d.) · Unknown authors · PubMed 23251661
ABSTRACT: Genetic variants responsible for susceptibility to obesity and its comorbidities among Hispanic children have not been identified. The VIVA LA FAMILIA Study was designed to genetically map childhood obesity and associated biological processes in the Hispanic population. A genome-wide association study (GWAS) entailed genotyping 1.1 million single nucleotide polymorphisms (SNPs) using the Illumina Infinium technology in 815 children. Measured genotype analysis was performed between genetic markers and obesity-related traits i.e., anthropometry, body composition, growth, metabolites, hormones, inflammation, diet, energy expenditure, substrate utilization and physical activity. Identified genome-wide significant loci: 1) corroborated genes implicated in other studies (MTNR1B, ZNF259
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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fasting glucose and lipid panel Moderate
Screen for metabolic complications associated with genetic obesity-related traits risk
Annual testing; discuss results with healthcare provider
Screening
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weight and waist circumference Moderate
rs11601602 associates with obesity-related traits through METTL15 expression effects on metabolic tissue function
Quarterly measurements; track trends with healthcare provider