rs11601321 - PKNOX2

Magnitude 4.5 · 1 study on file

Reported associations

• Genetic determinants of survival in patients with Alzheimer's disease - Unknown journal (n.d.) · Unknown authors · PubMed 25649651

  ABSTRACT: There is a strong genetic basis for late-onset of Alzheimer's disease (LOAD) and thus far >20 genes/loci have been identified that affect the risk of LOAD. In addition to disease risk, genetic variation at these loci may also affect components of the natural history of AD, such as survival in AD. In this study, we first examined the role of known LOAD genes with survival time in 983 AD patients. We then performed genome-wide single-nucleotide polymorphism (SNP) and gene-based association analyses to identify novel loci that may influence survival of AD. Survival analysis was conducted using Cox proportional hazards regression under an additive genetics model. We found multiple nominally significant associations (P<0.01) either within or adjacent to known LOAD genes. Genome-wide S

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