rs11600901 - SCN4B - SCN2B
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association study of preeclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort - Unknown journal (n.d.) · Unknown authors · PubMed 23551011
ABSTRACT: Summary A genome-wide association study was undertaken to identify maternal single nucleotide polymorphisms (SNPs) and copy-number variants (CNVs) associated with preeclampsia. Case-control analysis was performed on 1070 Afro-Caribbean (n=21 cases and 1049 controls) and 723 Hispanic (n=62 cases and 661 controls) mothers and 1257 mothers of European ancestry (n=50 cases and 1207 controls) from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study. European ancestry subjects were genotyped on Illumina Human610-Quad and Afro-Caribbean and Hispanic subjects were genotyped on Illumina Human1M-Duo BeadChip microarrays. Genome-wide SNP data were analyzed using PLINK. CNVs were called using three detection algorithms (GNOSIS, PennCNV, and QuantiSNP), merged using CNVision, and the
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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preeclampsia risk and pregnancy planning Moderate
Significant genetic association with preeclampsia warrants healthcare provider discussion of risk-specific monitoring and prevention strategies.
Discuss at preconception counseling or first prenatal visit
Screening
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blood pressure monitoring during pregnancy Moderate
Sodium channel variants affect vascular function; genetic association indicates elevated preeclampsia risk.
Monthly or more frequent blood pressure screening throughout pregnancy, starting at baseline assessment