rs1159970 - PCNX2

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity. - Human brain mapping (2019) · Smit DJA, Wright MJ, Meyers JL, Martin NG, Ho YYW, Malone SM, Zhang J, Burwell SJ, Chorlian DB, de Geus EJC, Denys D, Hansell NK, Hottenga JJ, McGue M, van Beijsterveldt CEM, Jahanshad N, Thompson PM, Whelan CD, Medland SE, Porjesz B, Lacono WG, Boomsma DI · PubMed 29947131

  Oscillatory activity is crucial for information processing in the brain, and has a long history as a biomarker for psychopathology. Variation in oscillatory activity is highly heritable, but current understanding of specific genetic influences remains limited. We performed the largest genome-wide association study to date of oscillatory power during eyes-closed resting electroencephalogram (EEG) across a range of frequencies (delta 1-3.75 Hz, theta 4-7.75 Hz, alpha 8-12.75 Hz, and beta 13-30 Hz) in 8,425 subjects. Additionally, we performed KGG positional gene-based analysis and brain-expression analyses. GABRA2-a known genetic marker for alcohol use disorder and epilepsy-significantly affected beta power, consistent with the known relation between GABA interneuron activity and beta os

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.