rs115944628 - NYAP2 - MIR5702

Magnitude 2.2 · 1 study on file

Reported associations

• Large-scale meta-genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types - Unknown journal (n.d.) · Unknown authors · PubMed 37862240

  ABSTRACT: Abstract Background This study was designed to identify common genetic susceptibility and shared genetic variants associated with acute radiation-induced toxicity across 4 cancer types (prostate, head and neck, breast, and lung). Methods A genome-wide association study meta-analysis was performed using 19 cohorts totaling 12 042 patients. Acute standardized total average toxicity (STATacute) was modelled using a generalized linear regression model for additive effect of genetic variants, adjusted for demographic and clinical covariates (rSTATacute). Linkage disequilibrium score regression estimated shared single-nucleotide variation (SNV-formerly SNP)-based heritability of rSTATacute in all patients and for each cancer type. Results Shared SNV-based heritability of STATacut

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