rs11592474
Magnitude 4.5 · 1 study on file
Reported associations
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Trans-ethnic meta-analysis identifies new loci associated with longitudinal blood pressure traits - Unknown journal (n.d.) · Unknown authors · PubMed 33603002
ABSTRACT: Genome-wide association studies (GWAS) have identified thousands of genetic loci associated with cross-sectional blood pressure (BP) traits; however, GWAS based on longitudinal BP have been underexplored. We performed ethnic-specific and trans-ethnic GWAS meta-analysis using longitudinal and cross-sectional BP data of 33,720 individuals from five cohorts in the US and one in Brazil. In addition to identifying several known loci, we identified thirteen novel loci with nine based on longitudinal and four on cross-sectional BP traits. Most of the novel loci were ethnic- or study-specific, with the majority identified in African Americans (AA). Four of these discoveries showed additional evidence of association in independent datasets, including an intergenic variant (rs4060030, p
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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cardiovascular risk from blood pressure genetics Moderate
genetic predisposition to elevated blood pressure warrants clinical evaluation
review findings with healthcare provider, assess family history and current BP status
Screening
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systolic blood pressure screening Moderate
rs11592474 A-allele associated with elevated systolic blood pressure (4.4 mmHg per allele)
baseline measurement and annual monitoring