Expressive

rs11590549 - CCDC17

Magnitude 2.2 · 1 study on file

Reported associations

  • Urate, Blood Pressure, and Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 33356394

    ABSTRACT: Supplemental Digital Content is available in the text. Serum urate has been implicated in hypertension and cardiovascular disease, but it is not known whether it is exerting a causal effect. To investigate this, we performed Mendelian randomization analysis using data from UK Biobank, Million Veterans Program and genome-wide association study consortia, and meta-analysis of randomized controlled trials. The main Mendelian randomization analyses showed that every 1-SD increase in genetically predicted serum urate was associated with an increased risk of coronary heart disease (odds ratio, 1.19 [95% CI, 1.10-1.30]; P=4×10−5), peripheral artery disease (1.12 [95% CI, 1.03-1.21]; P=9×10−3), and stroke (1.11 [95% CI, 1.05-1.18]; P=2×10−4). In Mendelian randomization med

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • serum urate levels Moderate

    CCDC17 variants are associated with elevated serum urate (GWAS p=4.0e-8), a key risk factor for gout and chronic kidney disease.

    Annual serum urate measurement, or more frequent testing if symptoms develop

Diet

  • high-purine foods Moderate

    Purine metabolism directly contributes to serum urate elevation; dietary purine reduction is an evidence-based strategy for managing hyperuricemia.

    Limit red meat, organ meats, and high-fructose beverages; moderate fish and legume intake

Discuss with your doctor

  • genetic risk for hyperuricemia and gout Moderate

    Early identification of genetic urate elevation risk allows preventive strategies including lifestyle modification and urate-lowering therapy if indicated.