rs115902351 - HCP5
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide Association Study Identifies HLA 8.1 Ancestral Haplotype Alleles as Major Genetic Risk Factors for Myositis Phenotypes - Unknown journal (n.d.) · Unknown authors · PubMed 26291516
ABSTRACT: Autoimmune muscle diseases (myositis) comprise a group of complex phenotypes influenced by genetic and environmental factors. To identify genetic risk factors in patients of European ancestry, we conducted a genome-wide association study (GWAS) of the major myositis phenotypes in a total of 1710 cases, which included 705 adult dermatomyositis; 473 juvenile dermatomyositis; 532 polymyositis; and 202 adult dermatomyositis, juvenile dermatomyositis or polymyositis patients with anti-histidyl tRNA synthetase (anti-Jo-1) autoantibodies, and compared them with 4724 controls. Single-nucleotide polymorphisms showing strong associations (P < 5 × 10−8) in GWAS were identified in the major histocompatibility complex (MHC) region for all myositis phenotypes together, as well as for the fo
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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monitor for myositis symptoms Moderate
rs115902351-G is strongly associated with myositis in genome-wide association (effect size 2.25)
Annual screening for muscle weakness and inflammation; establish baseline assessment with physician