Expressive

rs115889321 - MRPL42P6 - LINC02066

Magnitude 2.2 · 1 study on file

Reported associations

  • Novel genetic loci associated with osteoarthritis in multi-ancestry analyses in the Million Veteran Program and UK Biobank. - Nature genetics (2022) · McDonald MN, Lakshman Kumar P, Srinivasasainagendra V, Nair A, Rocco AP, Wilson AC, Chiles JW, Richman JS, Pinson SA, Dennis RA, Jagadale V, Brown CJ, Pyarajan S, Tiwari HK, Bamman MM, Singh JA · PubMed 36411363

    Osteoarthritis is a common progressive joint disease. As no effective medical interventions are available, osteoarthritis often progresses to the end stage, in which only surgical options such as total joint replacement are available. A more thorough understanding of genetic influences of osteoarthritis is essential to develop targeted personalized approaches to treatment, ideally long before the end stage is reached. To date, there have been no large multiancestry genetic studies of osteoarthritis. Here, we leveraged the unique resources of 484,374 participants in the Million Veteran Program and UK Biobank to address this gap. Analyses included participants of European, African, Asian and Hispanic descent. We discovered osteoarthritis-associated genetic variation at 10 loci and replicated

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • joint-protective low-impact aerobic and strength exercise Moderate

    Regular strengthening and low-impact activity prevent osteoarthritis progression and reduce symptom burden, especially in genetically susceptible individuals.

    150 min/week moderate aerobic activity, 2x/week resistance training for lower-body and core.

Lifestyle

  • maintain healthy body weight to reduce joint loading stress Moderate

    Excess weight increases osteoarthritis risk through direct joint loading and inflammatory pathways; weight management is particularly important for genetically susceptible individuals.

    Target BMI 18.5-24.9 if overweight, discuss weight management strategy with healthcare provider.

Screening

  • osteoarthritis risk assessment and baseline joint evaluation Moderate

    This SNP is associated with increased osteoarthritis risk in a large GWAS (n=1,285,436); carriers have 0.5-7% increased risk depending on genotype.

    Discuss baseline joint assessment and imaging strategy with healthcare provider if symptomatic.