rs11588454 - LINC02770
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans. - American journal of respiratory and critical care medicine (2025) · Cade BE, Chen H, Stilp AM, Gleason KJ, Sofer T, Ancoli-Israel S, Arens R, Bell GI, Below JE, Bjonnes AC, Chun S, Conomos MP, Evans DS, Johnson WC, Frazier-Wood AC, Lane JM, Larkin EK, Loredo JS, Post WS, Ramos AR, Rice K, Rotter JI, Shah NA, Stone KL, Taylor KD, Thornton TA, Tranah GJ, Wang C, Zee PC, Hanis CL, Sunyaev SR, Patel SR, Laurie CC, Zhu X, Saxena R, Lin X, Redline S · PubMed 26977737
Obstructive sleep apnea is a common disorder associated with increased risk for cardiovascular disease, diabetes, and premature mortality. Although there is strong clinical and epidemiologic evidence supporting the importance of genetic factors in influencing obstructive sleep apnea, its genetic basis is still largely unknown. Prior genetic studies focused on traits defined using the apnea-hypopnea index, which contains limited information on potentially important genetically determined physiologic factors, such as propensity for hypoxemia and respiratory arousability. To define novel obstructive sleep apnea genetic risk loci for obstructive sleep apnea, we conducted genome-wide association studies of quantitative traits in Hispanic/Latino Americans from three cohorts. Genome-wide data fro
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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obstructive sleep apnea screening Moderate
Variant rs11588454 is associated with increased apnea-hypopnea index in genome-wide association study
Discuss sleep apnea symptoms with physician; consider overnight sleep study if symptomatic