rs115863790 - NEDD9 - RNU1-64P

Magnitude 4.5 · 1 study on file

Reported associations

• Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population. - Pharmacogenomics (2017) · Hallberg P, Persson M, Axelsson T, Cavalli M, Norling P, Johansson HE, Yue QY, Magnusson PK, Wadelius C, Eriksson N, Wadelius M · PubMed 28084903

  We conducted a genome-wide association study on angiotensin-converting enzyme inhibitor-induced cough and used our dataset to replicate candidate genes identified in previous studies. A total of 124 patients and 1345 treated controls were genotyped using Illumina arrays. The genome-wide significance level was set to p < 5 × 10 . We identified nearly genome-wide significant associations in CLASP1, PDE11A, KCNMB2, TGFA, SLC38A6 and MMP16. The strongest association was with rs62151109 in CLASP1 (odds ratio: 3.97; p = 9.44 × 10 ). All top hits except two were located in intronic or noncoding DNA regions. None of the candidate genes were significantly associated in our study. Angiotensin-converting enzyme inhibitor-induced cough is potentially associated with genes that are independent of bra

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.